General Information
-
DRAMP ID
- DRAMP18641
-
Peptide Name
- KCM11
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- TWWRWW
-
Sequence Length
- 6
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.19734717] Gram-negative bacteria: Acidovorax konjaci(MEC=2.5 nM), Pseudomonas syringae pv. tomato DC3000 (MEC=5 nM), Pectobacterium carotovorum subsp. atrosepticum (MEC=5 nM), Xanthomonas albilineans (MEC=0.3 nM), Xanthomonas campestris pv. vesicatoria 833 (MEC=0.3 nM), Xanthomonas campestris pv. vesicatoria 833 pilA (MEC=0.3 nM), Xanthomonas oryzae pv. oryzae 599 (MEC=1.3 nM), Xanthomonas oryzae pv. oryzae 710 (MEC=1.3 nM), Xanthomonas oryzae pv. oryzae 090 (MEC=1.3 nM);
- Gram-positive bacterium: Clavibacter michiganensis subsp. michiganensis (MEC=0.3 nM)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18641.
Physicochemical Information
-
Formula
- C54H61N13O8
Absent Amino Acids
- ACDEFGHIKLMNPQSVY
Common Amino Acids
- W
Mass
- 1020.16
PI
- 9.41
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +1
-
Boman Index
- -817
Hydrophobicity
- -1.467
Aliphatic Index
- 0
Half Life
-
- Mammalian:7.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 22000
Absorbance 280nm
- 4400
Polar Residues
- 1
DRAMP18641
Comments Information
Function
- Low activity against the Gram-negative strains. High activity against the Gram-positive strains
Literature Information
- ·Literature 1
-
Title
- Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library.
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Pubmed ID
- 19734717
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Reference
- J Microbiol Biotechnol. 2009 Aug;19(8):792-802.
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Author
- Choi J, Moon E.