General Information
-
DRAMP ID
- DRAMP18645
-
Peptide Name
- PAF19
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RKTWFW
-
Sequence Length
- 6
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
-
Target Organism
-
- [Ref.11976121] Fungi: Penicillium digitatum PHI-26 (MIC=60 μM, IC50=36 ± 6 μM), Penicillium italicum PHI-1 (MIC=80 μM, IC50=52 ± 5 μM), Botrytis cinerea CECT2100 (MIC=80 μM, IC50=43 ± 14 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18645.
Physicochemical Information
-
Formula
- C47H62N12O8
Absent Amino Acids
- ACDEGHILMNPQSVY
Common Amino Acids
- W
Mass
- 923.08
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +2
-
Boman Index
- -1540
Hydrophobicity
- -1.35
Aliphatic Index
- 0
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 2200
Polar Residues
- 1
DRAMP18645
Comments Information
Function
- Antifungal activity against Penicillium digitatum PHI-26, Penicillium italicum PHI-1, Botrytis cinerea CECT2100. All residues of PAF19 are D-animo acids.
Literature Information
- ·Literature 1
-
Title
- Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
-
Pubmed ID
- 11976121
-
Reference
- Appl Environ Microbiol. 2002 May;68(5):2453-60.
-
Author
- López-García B, Pérez-Payá E, Marcos JF.