General Information
-
DRAMP ID
- DRAMP18647
-
Peptide Name
- PAF34
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RKWLFW
-
Sequence Length
- 6
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Antifungal
-
Target Organism
-
- [Ref.11976121] Fungi: Penicillium digitatum PHI-26 (MIC=40 μM, IC50=15 ± 1 μM), Penicillium italicum PHI-1 (MIC=20 μM, IC50=12 ± 4 μM), Penicillium expansum CMP-1 (MIC=160 μM, IC50> 80 μM), Botrytis cinerea CECT2100 (MIC=60 μM), Saccharomyces cerevisiae W303-1A (MIC>160 μM, IC50=52 ± 22 μM);
- Gram-negative bacterium: Escherichia coli DH5α(MIC=160 μM, IC50>80 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18647.
Physicochemical Information
-
Formula
- C49H66N12O7
Absent Amino Acids
- ACDEGHIMNPQSTVY
Common Amino Acids
- W
Mass
- 935.14
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +2
-
Boman Index
- -791
Hydrophobicity
- -0.6
Aliphatic Index
- 65
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 2200
Polar Residues
- 0
DRAMP18647
Comments Information
Function
- Antifungal activity against Penicillium digitatum PHI-26, Penicillium italicum PHI-1, Penicillium expansum CMP-1, Botrytis cinerea CECT2100, Saccharomyces cerevisiae W303-1A . Antibacterial activity against Escherichia coli DH5
Literature Information
- ·Literature 1
-
Title
- Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
-
Pubmed ID
- 11976121
-
Reference
- Appl Environ Microbiol. 2002 May;68(5):2453-60.
-
Author
- López-García B, Pérez-Payá E, Marcos JF.