General Information

    • DRAMP ID

    • DRAMP18649

    • Peptide Name

    • HLP6 (HLP2 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide HLP 2

    • Gene

    • Not found

    • Sequence

    • FQWQRNPRKVR

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 10418 (MIC=750 μM);
      • Gram-negative bacterium: Staphylococcus aureus (MIC=250 μM);
      • Clinical isolates: Acinetobacter sp.(MIC=10 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18649 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18649.

Physicochemical Information

    • Formula

    • C68H107N25O15

    • Absent Amino Acids

    • ACDEGHILMSTY

    • Common Amino Acids

    • R

    • Mass

    • 1514.76

    • PI

    • 12.3

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -5868

    • Hydrophobicity

    • -2.127

    • Aliphatic Index

    • 26.36

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 550

    • Polar Residues

    • 1

DRAMP18649

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. HLP 6 had a proline substituted for methionine in HLP 2.

Literature Information

  • ·Literature 1

    • Title

    • Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.

    • Reference

    • Infect Immun. 1998 Jun;66(6):2434-40.

    • Author

    • Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW.