General Information
-
DRAMP ID
- DRAMP18650
-
Peptide Name
- HLP7 (HLP2 peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide HLP 2
-
Gene
- Not found
-
Sequence
- FQWQRNMRKVR
-
Sequence Length
- 11
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 8007 (MIC=18 μM), Escherichia coli NCTC 10418 (MIC=40 μM);
- Gram-negative bacterium: Staphylococcus aureus (MIC=14 μM);
- Clinical isolates: Acinetobacter sp. (MIC=0.3 μM), Klebsiella sp. strain 3105 (MIC=80 μM), Providencia stuartii (MIC=110 μM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP18650_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C68H109N25O15S
Absent Amino Acids
- ACDEGHILPSTY
Common Amino Acids
- R
Mass
- 1548.83
PI
- 12.3
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -5633
Hydrophobicity
- -1.809
Aliphatic Index
- 26.36
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 550
Polar Residues
- 1
DRAMP18650
Comments Information
Function
- Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. HLP 7 is the d form of HLP 2.
Literature Information
- ·Literature 1
-
Title
- Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.
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Pubmed ID
- 9596699
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Reference
- Infect Immun. 1998 Jun;66(6):2434-40.
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Author
- Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW.