General Information
-
DRAMP ID
- DRAMP18651
-
Peptide Name
- Cm-p3 (Cm-p1 peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide Cm-p1
-
Gene
- Not found
-
Sequence
- SRSELIVHQRRC
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- [Ref.25921828] Fungi: Candida albicans (01U) (MIC=128 μg/ml), Candida albicans (38U) (MIC=64 μg/ml), Trichophyton rubrum (MIC=128 μg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18651.
Physicochemical Information
-
Formula
- C60H106N24O18S
Absent Amino Acids
- ADFGKMNPTWY
Common Amino Acids
- R
Mass
- 1483.71
PI
- 10.26
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 3
Net Charge
- +3
-
Boman Index
- -5341
Hydrophobicity
- -0.858
Aliphatic Index
- 89.17
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP18651
Comments Information
Function
- Antifungal activity against Candida albicans and Trichophyton rubrum.
Literature Information
- ·Literature 1
-
Title
- Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae).
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Pubmed ID
- 25921828
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Reference
- FASEB J. 2015 Aug;29(8):3315-25.
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Author
- López-Abarrategui C, McBeth C, Mandal SM, Sun ZJ, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, García-Villarino M, Nolasco DO, Falcão R, Cherobim MD, Dias SC, Brandt W, Wessjohann L, Starnbach M, Franco OL, Otero-González AJ.