General Information

    • DRAMP ID

    • DRAMP18653

    • Peptide Name

    • Cm-p5 (Cm-p1 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Cm-p1

    • Gene

    • Not found

    • Sequence

    • SRSELIVHQRLF

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • [Ref.25921828] Fungi: Candida albicans (01U) (MIC=10 μg/ml), Candida albicans (38U) (MIC=10 μg/ml), Candida parapsilosis (MIC=32 μg/ml), Cryptococcus neoformans (L26) (MIC=64 μg/ml), Cryptococcus neoformans (L30) (MIC=64 μg/ml), Trichophyton mentagrophytes (MIC=128 μg/ml), Trichophyton rubrum (MIC=10 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18653 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18653.

Physicochemical Information

    • Formula

    • C66H109N21O18

    • Absent Amino Acids

    • ACDGKMNPTWY

    • Common Amino Acids

    • LRS

    • Mass

    • 1484.72

    • PI

    • 9.34

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -3187

    • Hydrophobicity

    • -0.142

    • Aliphatic Index

    • 121.67

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18653

Comments Information

    • Function

    • Antifungal activity against Candida albicans, Candida parapsilosis, Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum.

Literature Information

  • ·Literature 1

    • Title

    • Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae).

    • Reference

    • FASEB J. 2015 Aug;29(8):3315-25.

    • Author

    • López-Abarrategui C, McBeth C, Mandal SM, Sun ZJ, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, García-Villarino M, Nolasco DO, Falcão R, Cherobim MD, Dias SC, Brandt W, Wessjohann L, Starnbach M, Franco OL, Otero-González AJ.