General Information

    • DRAMP ID

    • DRAMP18655

    • Peptide Name

    • dPSMα4 (PSMα4 peptide derivative; bacteriocin; staphylococcus aureus, bacteria)

    • Source

    • Truncated the peptide PSMα4 (from Staphylococcus aureus)

    • Family

    • Belongs to the phenol-soluble modulin alpha peptides family.

    • Gene

    • psmA4

    • Sequence

    • VGTIIKIIKAIIDIFAK

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.22371493]Gram-positive bacteria: Streptococcus serotype GAS M3 strain 4041-05 (MIC=10 μM).

    • Hemolytic Activity

      • [Ref.22371493]52% hemolysis at 10μg/mL against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18655 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18655.

Physicochemical Information

    • Formula

    • C90H158N20O21

    • Absent Amino Acids

    • CEHLMNPQRSWY

    • Common Amino Acids

    • I

    • Mass

    • 1856.37

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 1808

    • Hydrophobicity

    • 1.518

    • Aliphatic Index

    • 189.41

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18655

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria. Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection. Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8). The ensuing activation process triggers an inflammatory response in the host, thus contributing greatly to virulence. Also possesses hemolytic activity, which may contribute to the development of disease. Peptide production is higher in most prevalent community-associated MRSA strains than in hospital-associated MRSA strains.

    • Induction

    • Up-regulated by agr.

Literature Information

  • ·Literature 1

    • Title

    • Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry.

    • Reference

    • J Biol Chem. 2012 Apr 20;287(17):13889-98.

    • Author

    • Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V.