General Information
-
DRAMP ID
- DRAMP18661
-
Peptide Name
- Ctx-Ha (Frogs, amphibians, animals)
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Source
- Hypsiboas albopunctatus
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Family
- Belongs to the Ceratotoxin family
-
Gene
- Not found
-
Sequence
- GWLDVAKKIGKAAFNVAKNFL
-
Sequence Length
- 21
-
UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-
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Target Organism
-
- [Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=1.7 μmol/L; MMC=6.8 μmol/L);
- Gram-negative bacterium: Escherichia coli (MIC=3.4 μmol/L; MMC=3.4 μmol/L);
- Fungi: Candida albicans (MIC=54.6 μmol/L; MMC<100 μmol/L)
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Hemolytic Activity
-
- [Ref.22391524]HC50=37.3±1.4 μmol/L against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18661.
Physicochemical Information
-
Formula
- C109H172N28O26
Absent Amino Acids
- CEHMPQRSTY
Common Amino Acids
- AK
Mass
- 2290.74
PI
- 10
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 12
Net Charge
- +3
-
Boman Index
- -395
Hydrophobicity
- 0.262
Aliphatic Index
- 102.38
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 275
Polar Residues
- 4
DRAMP18661
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
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Pubmed ID
- 22391524
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Reference
- Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.
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Author
- Lorenzón EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM.