• • DRAMP ID

  • DRAMP18666

• • Peptide Name

  • P1 (Pilosulin-1 1-20; Ant, insects, arthropods, invertebrates, animals)

• • Source

  • Myrmecia pilosula (Jumper ant)

• • Family

  • Derived from the peptide Pilosulin-1, Belongs to the pilosulin family.

• • Gene

  • Not found

• • Sequence

  • GLGSVFGRLARILGRVIPKV

• • Sequence Length

  • 20

• • UniProt Entry

  • Q07932

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-

• • Target Organism

  • • [Ref.15639237]Gram-positive bacteria: Staphylococcus aureus 710A (MIC=4 μM), Bacillus megaterium BM11 (MIC=2 μM);
    • Gram-negative bacteria: Escherichia coli ML-35 (MIC=2 μM), Pseudomonas aeruginosa ATCC27853 (MIC=8 μM), Salmonella typhimurium ATCC14028 (MIC=8 μM).
    • Drug resistant clinical isolates: Staphylococcus simulans 22 (MIC=2 μM), Micrococcus luteus (MIC=0.5 μM), Enterococcus spp. I-11305b (MIC=2 μM), Enterococcus spp. I-11054 (MIC=2 μM), Staphylococcus haemolyticus I-10925 (MIC=2 μM), Staphylococcus epidermidis LT1324 (MIC=2 μM), Staphylococcus aureus 5185 (MIC=2 μM), Staphylococcus aureus I-11574 (MIC=2 μM), Staphylococcus aureus LT1338 (MIC=3 μM), Staphylococcus aureus T1334 (MIC=1.5 μM), Citrobacter freundii I-11090 (MIC=2 μM), Klebsiella pneumoniae I-10910 (MIC=2 μM), Escherichia coli I-11276b (MIC=4 μM), Escherichia coli O-19592 (MIC=2 μM), Stenotrophomonas maltophilia O-16451 (MIC=2 μM), Stenotrophomonas maltophilia I-10717 (MIC=2 μM), Pseudomonas aeruginosa 4991 (MIC=4 μM), Pseudomonas aeruginosa I-10968 (MIC=4 μM), Candida albicans I-11301 (MIC=4 μM).

• • Hemolytic Activity

  • • [Ref.15639237]20% hemolysis at 10μM, 100% hemolysis at 100μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 5X3L resolved by NMR.
• 5X3L-> 

• Predicted Structure

• Please click DRAMP18666_predicted_structure.pdb to download.

DRAMP18666

• • Function

  • Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Adopts an alpha-helical structure.

• • Allergenic properties

  • Causes an allergic reaction in human. Binds to IgE.

• ·Literature 1

• • Title

  • Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.

• • Pubmed ID

  • 15639237

• • Reference

  • Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.

• • Author

  • Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.