General Information

    • DRAMP ID

    • DRAMP18667

    • Peptide Name

    • Pep-1

    • Source

    • Derived from the nuclear localization sequence of simian virus 40 large T antigen and from reverse t

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KETWWETWWTEWSQPKKKRKV

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=8.0 μM), Staphylococcus aureus (KCTC 1621) (MIC=64.0 μM), Staphylococcus epidermidis (KCTC 1917) (MIC=64.0 μM);
      • Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=32.0 μM);
      • Antibiotic-resistant bacteria: MDRPA 1 (CCARM 2092) (MIC=32.0 μM), MDRPA 3 (CCARM 2109) (MIC=32.0 μM).

    • Hemolytic Activity

      • [Ref.16945333]Non-hemolysis at 200 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18667 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18667.

Physicochemical Information

    • Formula

    • C136H195N35O33

    • Absent Amino Acids

    • ACDFGHILMNY

    • Common Amino Acids

    • KW

    • Mass

    • 2848.26

    • PI

    • 9.82

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -6406

    • Hydrophobicity

    • -2.038

    • Aliphatic Index

    • 13.81

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 27500

    • Absorbance 280nm

    • 1375

    • Polar Residues

    • 4

DRAMP18667

DRAMP18667 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria.No hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1.

    • Reference

    • Biochem Biophys Res Commun. 2006 Oct 20;349(2):769-74.

    • Author

    • Zhu WL, Lan H, Park IS, Kim JI, Jin HZ, Hahm KS, Shin SY.