General Information

    • DRAMP ID

    • DRAMP18668

    • Peptide Name

    • AI-hemocidins 1 (Hb-1 truncated peptide)

    • Source

    • Arca inflata

    • Family

    • Belongs to truncated Hb-1

    • Gene

    • Not found

    • Sequence

    • PSVQGAAAQLTADVKK

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.28661457] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=47.35 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=47.35 μM), Pseudomonas aeruginosa clinical isolate (MIC=47.35 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18668 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18668.

Physicochemical Information

    • Formula

    • C68H118N20O23

    • Absent Amino Acids

    • CEFHIMNRWY

    • Common Amino Acids

    • A

    • Mass

    • 1583.81

    • PI

    • 9.01

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • -1569

    • Hydrophobicity

    • -0.15

    • Aliphatic Index

    • 85.63

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18668

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata

    • Reference

    • Mar Drugs. 2017 Jun 29;15(7). pii: E205.

    • Author

    • Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R.