General Information

    • DRAMP ID

    • DRAMP18669

    • Peptide Name

    • AI-hemocidins 3 (Hb-1 truncated peptide)

    • Source

    • Arca inflata

    • Family

    • Belongs to truncated Hb-1

    • Gene

    • Not found

    • Sequence

    • ISAAEFGKINGPIKK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.28661457] Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853 (MIC=95.37 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18669 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18669.

Physicochemical Information

    • Formula

    • C72H121N19O20

    • Absent Amino Acids

    • CDHLMQRTVWY

    • Common Amino Acids

    • IK

    • Mass

    • 1572.87

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -1026

    • Hydrophobicity

    • -0.133

    • Aliphatic Index

    • 91.33

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18669

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata

    • Reference

    • Mar Drugs. 2017 Jun 29;15(7). pii: E205.

    • Author

    • Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R.