General Information

    • DRAMP ID

    • DRAMP18671

    • Peptide Name

    • TO17 (TFPI-1 C-terminal peptide)

    • Source

    • Red drum (Sciaenops ocellatus)

    • Family

    • Belongs to the TFPI-1 C-terminal peptide

    • Gene

    • Not found

    • Sequence

    • KCRRRKVHGPMIRIRKK

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29183811] Gram-positive bacteria: Micrococcus luteus (MIC=9 μM; MBC=18 μM), Staphylococcus aureus (MIC=4 μM; MBC=8 μM);
      • Gram-negative bacterium: Vibrio vulnificus (MIC= 80 μM; MBC=80 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18671 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18671.

Physicochemical Information

    • Formula

    • C92H172N38O18S2

    • Absent Amino Acids

    • ADEFLNQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 2162.74

    • PI

    • 12.19

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +10

    • Boman Index

    • -8301

    • Hydrophobicity

    • -1.512

    • Aliphatic Index

    • 62.94

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18671

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus.

    • Reference

    • Fish Shellfish Immunol. 2018 Jan;72:639-645.

    • Author

    • He SW, Wang GH, Yue B, Zhou S, Zhang M.