General Information

    • DRAMP ID

    • DRAMP18677

    • Peptide Name

    • Peptide 6 (Mollusca/molluscs/mollusks, invertebrates, animals)

    • Source

    • Marine snail Rapana venosa

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SPPPGESKVDMSFNYALSNPAQ

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;
      • Gram-negative bacterium: Klebsiella pneumoniae

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18677 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18677.

Physicochemical Information

    • Formula

    • C102H154N26O35S

    • Absent Amino Acids

    • CHIRTW

    • Common Amino Acids

    • PS

    • Mass

    • 2336.56

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -1

    • Boman Index

    • -3479

    • Hydrophobicity

    • -0.746

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 70.95

    • Polar Residues

    • 8

DRAMP18677

DRAMP18677 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacterium.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.

    • Reference

    • Peptides. 2011 Jul;32(7):1477-83.

    • Author

    • Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W.