General Information
-
DRAMP ID
- DRAMP18680
-
Peptide Name
- Ctry2146 (Scorpions, animals)
-
Source
- Chaerilus tryznai (Scorpion)
-
Family
- Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant
-
Gene
- Not found
-
Sequence
- GIADILKGLL
-
Sequence Length
- 10
-
UniProt Entry
- P0DMF1
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
- [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFNα.2a) in Huh7.5.1 cells.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18680.
Physicochemical Information
-
Formula
- C47H85N11O13
Absent Amino Acids
- CEFHMNPQRSTVWY
Common Amino Acids
- L
Mass
- 1012.26
PI
- 5.84
Basic Residues
- 1
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- 0
-
Boman Index
- 1402
Hydrophobicity
- 1.4
Aliphatic Index
- 205
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP18680
Comments Information
Function
- Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells.
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
-
Title
- Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.
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Pubmed ID
- 23415044
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Reference
- Biomaterials. 2013 Apr;34(13):3511-22.
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Author
- Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.