General Information

    • DRAMP ID

    • DRAMP18683

    • Peptide Name

    • Ctri9194 (Scorpions, animals)

    • Source

    • Chaerilus tricostatus (Scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant

    • Gene

    • Not found

    • Sequence

    • YIRDFITRRPPFGNI

    • Sequence Length

    • 15

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFNα.2a) in Huh7.5.1 cells.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18683 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18683.

Physicochemical Information

    • Formula

    • C87H133N25O21

    • Absent Amino Acids

    • ACEHKLMQSVW

    • Common Amino Acids

    • IR

    • Mass

    • 1865.17

    • PI

    • 10.74

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -4117

    • Hydrophobicity

    • -0.467

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 106.43

    • Polar Residues

    • 4

DRAMP18683

Comments Information

    • Function

    • Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

    • Reference

    • Biomaterials. 2013 Apr;34(13):3511-22.

    • Author

    • Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.