General Information
-
DRAMP ID
- DRAMP18686
-
Peptide Name
- Ctri9610 (Scorpions, animals)
-
Source
- Chaerilus tricostatus (Scorpion)
-
Family
- Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant
-
Gene
- Not found
-
Sequence
- FLFNVIPHAINATASLIKK
-
Sequence Length
- 19
-
UniProt Entry
- P0DME2
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
- [Ref.23415044] The HCV RNA level is screened that between 1.E-01% and 1.E+00% of control(IFNα.2a) in Huh7.5.1 cells.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18686.
Physicochemical Information
-
Formula
- C100H161N25O24
Absent Amino Acids
- CDEGMQRWY
Common Amino Acids
- AI
Mass
- 2097.53
PI
- 10
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- 502
Hydrophobicity
- 0.8
Aliphatic Index
- 133.68
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP18686
Comments Information
Function
- Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells.
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
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Title
- Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.
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Pubmed ID
- 23415044
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Reference
- Biomaterials. 2013 Apr;34(13):3511-22.
-
Author
- Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.