General Information

    • DRAMP ID

    • DRAMP18687

    • Peptide Name

    • Ctri10033 (Scorpions, animals)

    • Source

    • Chaerilus tricostatus (Scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant

    • Gene

    • Not found

    • Sequence

    • FLVGILPRMRGFITPFLKKVR

    • Sequence Length

    • 21

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFNα.2a) in Huh7.5.1 cells.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18687 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18687.

Physicochemical Information

    • Formula

    • C120H198N32O23S

    • Absent Amino Acids

    • ACDEHNQSWY

    • Common Amino Acids

    • FLR

    • Mass

    • 2489.15

    • PI

    • 12.31

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • -1258

    • Hydrophobicity

    • 0.624

    • Aliphatic Index

    • 120.48

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18687

DRAMP18687 chydropathy plot

Comments Information

    • Function

    • Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

    • Reference

    • Biomaterials. 2013 Apr;34(13):3511-22.

    • Author

    • Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.