• • DRAMP ID

  • DRAMP18693

• • Peptide Name

  • Substance P (Mammals, animals)

• • Source

  • Not found

• • Family

  • Belongs to the tachykinin family.

• • Gene

  • TAC1

• • Sequence

  • RPKPQQFFGLM

• • Sequence Length

  • 11

• • UniProt Entry

  • P67932,P67933

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.12074933]Gram-negative bacteria: Escherichia coli (MIC=0.06%), Proteus vulgaris (MIC=0.13%), Pseudomonas aeruginosa (MIC=0.13%) ;
    • Gram-positive bacteria: Staphylococcus aureus (MIC=0.007%), Enterococcus faecalis (MIC=0.13%);
    • Yeast: Candida albicans (MIC=0.25%)

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18693.

DRAMP18693

• • Function

  • Substance P possesses direct antimicrobial activity. Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

• ·Literature 1

• • Title

  • Direct antimicrobial properties of substance P.

• • Pubmed ID

  • 12074933

• • Reference

  • Life Sci. 2002 Jul 5;71(7):747-50.

• • Author

  • Kowalska K, Carr DB, Lipkowski AW.