General Information
-
DRAMP ID
- DRAMP18694
-
Peptide Name
- substance P antagonist (Mammals, animals)
-
Source
- Not found
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RPKPQQWFWLM
-
Sequence Length
- 11
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- [Ref.12074933]Gram-negative bacteria: Escherichia coli (MIC=0.13%), Proteus vulgaris (MIC=0.13%), Pseudomonas aeruginosa (MIC=0.13%) ;
- Gram-positive bacteria: Staphylococcus aureus (MIC=0.13%), Enterococcus faecalis (MIC=0.13%);
- Yeast: Candida albicans (MIC=0.03%).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18694.
Physicochemical Information
-
Formula
- C74H105N19O14S
Absent Amino Acids
- ACDEGHINSTVY
Common Amino Acids
- PQW
Mass
- 1516.83
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +2
-
Boman Index
- -1664
Hydrophobicity
- -1.082
Aliphatic Index
- 35.45
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 1100
Polar Residues
- 0
DRAMP18694
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Direct antimicrobial properties of substance P.
-
Pubmed ID
- 12074933
-
Reference
- Life Sci. 2002 Jul 5;71(7):747-50.
-
Author
- Kowalska K, Carr DB, Lipkowski AW.