• DRAMP ID

    • DRAMP18694
    • Peptide Name

    • substance P antagonist (Mammals, animals)
    • Source

    • Not found
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RPKPQQWFWLM
    • Sequence Length

    • 11
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.12074933]Gram-negative bacteria: Escherichia coli (MIC=0.13%), Proteus vulgaris (MIC=0.13%), Pseudomonas aeruginosa (MIC=0.13%) ;
      • Gram-positive bacteria: Staphylococcus aureus (MIC=0.13%), Enterococcus faecalis (MIC=0.13%);
      • Yeast: Candida albicans (MIC=0.03%).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18694 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18694.
    • Formula

    • C74H105N19O14S
    • Absent Amino Acids

    • ACDEGHINSTVY
    • Common Amino Acids

    • PQW
    • Mass

    • 1516.83
    • PI

    • 11
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +2
    • Boman Index

    • -1664
    • Hydrophobicity

    • -1.082
    • Aliphatic Index

    • 35.45
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 1100
    • Polar Residues

    • 0

DRAMP18694

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.
  • ·Literature 1
    • Title

    • Direct antimicrobial properties of substance P.
    • Reference

    • Life Sci. 2002 Jul 5;71(7):747-50.
    • Author

    • Kowalska K, Carr DB, Lipkowski AW.