General Information

    • DRAMP ID

    • DRAMP18696

    • Peptide Name

    • HLP1 (Lactotransferrin truncated peptide)

    • Source

    • Homo sapiens (Human)

    • Family

    • Belongs to the Lactotransferrin

    • Gene

    • LTF

    • Sequence

    • FQWQRNMRKVRGPPVS

    • Sequence Length

    • 16

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 8007 (MIC=500 μM), Escherichia coli NCTC 10418 (MIC=500μM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=500 μM);
      • Clinical isolates: Acinetobacter sp.(MIC=2 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18696 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C88H140N30O21S

    • Absent Amino Acids

    • ACDEHILTY

    • Common Amino Acids

    • R

    • Mass

    • 1986.33

    • PI

    • 12.3

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +4

    • Boman Index

    • -5475

    • Hydrophobicity

    • -1.256

    • Aliphatic Index

    • 36.25

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 366.67

    • Polar Residues

    • 3

DRAMP18696

Comments Information

    • Function

    • Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. HLP 1 corresponded to the loop region of human lactoferricin (residues 20 to 35).

Literature Information

  • ·Literature 1

    • Title

    • Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.

    • Reference

    • Infect Immun. 1998 Jun;66(6):2434-40.

    • Author

    • Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW.