General Information

    • DRAMP ID

    • DRAMP18698

    • Peptide Name

    • Histone H2A (Trouts, fish, animals)

    • Source

    • Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

    • Family

    • Belongs to the histone H2A family.

    • Gene

    • Not found

    • Sequence

    • AERVGAGAPVYL

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • [Ref.12164782] Gram positive bacteria: Aerococcus viridans (MIC=0.08-0.15 µM), Bacillus subtilis (MIC=0.6-1.2 µM), Micrococcus luteus (MIC=0.6-1.2 µM), Planococcus citreus (MIC=0.08-0.15 µM), Renibacterium salmoninarum (MIC=0.15-0.3 µM);
      • Fungi: Saccharomyces cerevisiae (MIC=0.3-0.6 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18698 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18698.

Physicochemical Information

    • Formula

    • C54H87N15O16

    • Absent Amino Acids

    • CDFHIKMNQSTW

    • Common Amino Acids

    • A

    • Mass

    • 1202.38

    • PI

    • 6.05

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • -156

    • Hydrophobicity

    • 0.492

    • Aliphatic Index

    • 105.83

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 3

DRAMP18698

Comments Information

    • Function

    • The secreted form has antibacterial activity against Gram-positive bacteria and antifungal activity against Saccharomyces cerevisiae.

    • Tissue specificity

    • Expressed and secreted by skin epithelium.

Literature Information

  • ·Literature 1

    • Title

    • Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykiss.

    • Reference

    • Biochem J. 2002 Dec 1;368(Pt 2):611-20.

    • Author

    • Fernandes JMO., Kemp GD., Molle MG., Smith VJ.2002