General Information

    • DRAMP ID

    • DRAMP18700

    • Peptide Name

    • Pleurain-C1 (Frogs, amphibians, animals)

    • Source

    • Rana pleuraden (Yunnan pond frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.

    • Gene

    • Not found

    • Sequence

    • YPELQQDLIARLL

    • Sequence Length

    • 13

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=50 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 μg/ml), Bacillus subtilis (MIC=3.1 μg/ml);
      • Yeast: Candida albicans(MIC=25 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18700 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C72H118N18O21

    • Absent Amino Acids

    • CFGHKMNSTVW

    • Common Amino Acids

    • L

    • Mass

    • 1571.84

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -1

    • Boman Index

    • -1526

    • Hydrophobicity

    • 0.008

    • Aliphatic Index

    • 157.69

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 124.17

    • Polar Residues

    • 1

DRAMP18700

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

Literature Information

  • ·Literature 1

    • Title

    • Antioxidant peptidomics reveals novel skin antioxidant system.

    • Reference

    • Mol Cell Proteomics. 2009 Mar;8(3):571-83.

    • Author

    • Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R.