General Information

    • DRAMP ID

    • DRAMP18711

    • Peptide Name

    • Chicken Heterophil Peptide 2 (CHP-2, avian beta-defensin, birds, animals)

    • Source

    • Gallus gallus (Chicken)

    • Family

    • Belongs to the beta-defensin family.

    • Gene

    • Not found

    • Sequence

    • GRKSDCFRKNGFCAFLKCPYLTLISGLCSFHLC

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18711 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C167H259N45O42S5

    • Absent Amino Acids

    • EMQVW

    • Common Amino Acids

    • CL

    • Mass

    • 3729.47

    • PI

    • 9.04

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +5

    • Boman Index

    • -2695

    • Hydrophobicity

    • 0.33

    • Aliphatic Index

    • 73.94

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1740

    • Absorbance 280nm

    • 54.38

    • Polar Residues

    • 14

DRAMP18711

DRAMP18711 chydropathy plot

Comments Information

    • Function

    • Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of antimicrobial peptides from avian heterophils.

    • Reference

    • J. Leukoc. Biol. 1994; 56: 661-665.

    • Author

    • Evans EW, Beach GG, Wunderlich J, Harmon BG.