General Information
-
DRAMP ID
- DRAMP18717
-
Peptide Name
- Charybdotoxin (Yellow scorpions, arachnids, Chelicerata, arthropods, invertebrates, animals)
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Source
- Leiurus quinquestriatus hebraeus
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Family
- Not found
-
Gene
- Not found
-
Sequence
- EFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS
-
Sequence Length
- 37
-
UniProt Entry
- No entry found
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.15118082]Gram-positive bacteria: Bacillus subtilis (Inhibition zone=4 mm completely inhibit in PH5.5, Inhibition zone=7 mm incompletely inhibit and Inhibition zone=6 mm in PH7.5 completely inhibit at 10 μg/well), Staphylococcus aureus (Inhibition zone=3 mm incompletely inhibit in PH5.5, Inhibition zone=6 mm incompletely inhibit and Inhibition zone=1 mm completely inhibit in PH7.5 at 10 μg/well);
- Gram-negative bacteria: Escherichia coli (Inhibition zone=2 mm incompletely inhibit in PH5.5, Inhibition zone=8 mm incompletely inhibit in PH7.5 at 10 μg/well);
- Fungi: Candida albicans (Inhibition zone=13 mm completely inhibit in PH5.5, Inhibition zone=15 mm in PH7.5 completely inhibit at 10 μg/well).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Combine Helix and Beta structure
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- 2CRD resolved by NMR
- 2CRD-> 
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Predicted Structure
- There is no predicted structure for DRAMP18717.
Physicochemical Information
-
Formula
- C176H285N57O56S7
Absent Amino Acids
- ADIP
Common Amino Acids
- C
Mass
- 4319.97
PI
- 9.13
Basic Residues
- 8
Acidic Residues
- 2
Hydrophobic Residues
- 5
Net Charge
- +6
-
Boman Index
- -10884
Hydrophobicity
- -0.832
Aliphatic Index
- 26.22
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7365
Absorbance 280nm
- 204.58
Polar Residues
- 20
DRAMP18717
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Multidimensional signatures in antimicrobial peptides.
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Pubmed ID
- 15118082
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Reference
- Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.
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Author
- Yount NY, Yeaman MR.