General Information
-
DRAMP ID
- DRAMP18722
-
Peptide Name
- MA (Magainin 2 (9-21) truncated peptide)
-
Source
- Xenopus laevis (African clawed frog)
-
Family
- Belongs to truncated magainin 2.
-
Gene
- magainins
-
Sequence
- AKKFGKAFVGEIM
-
Sequence Length
- 13
-
UniProt Entry
- P11006
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
-
Target Organism
-
- [Ref.28178190] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=32 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18722.
Physicochemical Information
-
Formula
- C67H108N16O16S
Absent Amino Acids
- CDHLNPQRSTWY
Common Amino Acids
- K
Mass
- 1425.75
PI
- 9.7
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +2
-
Boman Index
- -69
Hydrophobicity
- 0.292
Aliphatic Index
- 67.69
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP18722
Comments Information
Function
- Antibacterial activity against the Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
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Pubmed ID
- 28178190
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Reference
- Int J Mol Sci. 2017 Feb 6;18(2). pii: E339.
-
Author
- Tan T, Wu D, Li W, Zheng X, Li W, Shan A.