• DRAMP ID

    • DRAMP18724
    • Peptide Name

    • Oncorhyncin III (Oncorhyncin-3, histone-derived; fish, animals)
    • Source

    • Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    • Family

    • Belongs to the HMGN family.
    • Gene

    • Unknown
    • Sequence

    • PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK
    • Sequence Length

    • 69
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.12713443] Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 μM), Bacillus subtilis (MIC=0.25-0.5 μM), Micrococcus luteus (MIC=0.12-0.25 μM), Planococcus citerus (MIC=0.06-0.12 μM);
      • Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 μM), Aeromonas salmonicida (MIC>0.5 μM), Escherichia coli (MIC=0.25-0.5 μM), Listonella anguillarum (MIC=0.25-0.5 μM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknownn
    • DRAMP18724 helical wheel diagram
    • Formula

    • C298H520N102O89
    • Absent Amino Acids

    • CFHIMWY
    • Common Amino Acids

    • A
    • Mass

    • 816915
    • PI

    • 11.51
    • Basic Residues

    • 20
    • Acidic Residues

    • 6
    • Hydrophobic Residues

    • 23
    • Boman Index

    • -17896
    • Hydrophobicity

    • -113.91
    • Aliphatic Index

    • 45.8
    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 12

DRAMP18724

DRAMP18724 chydropathy plot
    • Function

    • Oncorhyncin III has antibacterial activity against Gram-positive and Gram-negative bacteria at submicromolar concentrations. Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer.
  • Literature 1
    • Reference

    • Biochem 2003; 373 (Pt 2): 621-628
    • Author

    • Fernandes JM., Saint N, Kemp GD, Smith VJ.
    • Title

    • Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss.