• DRAMP ID

    • DRAMP20764
    • Peptide Name

    • Halocin R1 (HalR1, Halocin-R1; Microhalocins, Archaeocin, Bacteriocin, Archaea, Euryarchaeota, Prokaryotes)
    • Source

    • Halobacterium sp. GN101
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • LQSNININTAAAVILIFNQVQVGALCAPTPVSGGGPVP
    • Sequence Length

    • 38
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

      • [Ref.11114928] Archaea: Sulfolobus solfataricus (Inhibition Zone=7mm)
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknownn
    • DRAMP20764 helical wheel diagram
    • Formula

    • C167H275N45O50S
    • Absent Amino Acids

    • DEHKMRWY
    • Common Amino Acids

    • AV
    • Mass

    • 3745.35
    • PI

    • 5.52
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 22
    • Boman Index

    • -0.44
    • Hydrophobicity

    • 0.77
    • Aliphatic Index

    • 123.16
    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 16

DRAMP20764

DRAMP20764 chydropathy plot
    • Function

    • HalR1 is a microhalocin ( 38 amino acids ), and even more intriguing, HalR1 is 63% identical and 71% similar to HalS8
    • (identical residues in capitals ) . HalR1 is not cationic like typical bacteriocins and eucaryocins, it will be interesting to discover their mechanisms of action.

  • Literature 1
    • Reference

    • J Ind Microbiol Biotechnol. 2002 Jan;28(1):23-31.
    • Author

    • O'Connor EM, Shand RF.
    • Title

    • Halocins and sulfolobicins: the emerging story of archaeal protein and peptide antibiotics.
  • Literature 2
    • Reference

    • J Bacteriol. 2001 Jan;183(1):287-91.
    • Author

    • Haseltine C, Hill T, Montalvo-Rodriguez R, Kemper SK, Shand RF, Blum P.
    • Title

    • Secreted euryarchaeal microhalocins kill hyperthermophilic crenarchaea.