General Information

    • DRAMP ID

    • DRAMP20775

    • Peptide Name

    • Ctry2459-WT (Ctry2459, scorpions,animals)

    • Source

    • Chaerilus tryznai (Scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.

    • Gene

    • Not found

    • Sequence

    • FLGFLKNLF

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.23415044] Virus: Hepatitis C virus (EC50=1.84 μg/ml).
      • Cytotoxic: Huh7.5.1 cells (CC50=79.8 μg/ml)

    • Hemolytic Activity

      • [Ref.23415044] HC50 = 137.9 μg/ml against human red blood cells.

    • Cytotoxicity

      • [Ref.23415044] CC50=79.8 μg/ml against Huh7.5.1 cells.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20775 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20775.

Physicochemical Information

    • Formula

    • C57H83N11O11

    • Absent Amino Acids

    • ACDEHIMPQRSTVWY

    • Common Amino Acids

    • FL

    • Mass

    • 1098.35

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • 1245

    • Hydrophobicity

    • 1.333

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP20775

Comments Information

    • Function

    • Inhibit hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes.

Literature Information

  • ·Literature 1

    • Title

    • Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

    • Reference

    • Biomaterials. 2013 Apr;34(13):3511-22.

    • Author

    • Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.