• DRAMP ID

    • DRAMP20775
    • Peptide Name

    • Ctry2459-WT (Ctry2459, scorpions,animals)
    • Source

    • Chaerilus tryznai (Scorpion)
    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
    • Gene

    • Unknown
    • Sequence

    • FLGFLKNLF
    • Sequence Length

    • 9
    • Evidence code

    • Protein level
    • Biological Activity

    • Antiviral, Antimicrobial
    • Target Organism

      • [Ref.23415044] Virus: Hepatitis C virus (EC50=1.84 μg/ml).
      • Cytotoxic: Huh7.5.1 cells (CC50=79.8 μg/ml)
    • Hemolytic activity

      • [Ref.23415044] HC50 = 137.9 μg/ml against human red blood cells.
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP20775 helical wheel diagram
    • Formula

    • C57H83N11O11
    • Absent Amino Acids

    • ACDEHIMPQRSTVWY
    • Common Amino Acids

    • FL
    • Mass

    • 1098.35
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Boman Index

    • 1245
    • Hydrophobicity

    • 133.33
    • Aliphatic Index

    • 130
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP20775

    • Function

    • Inhibit hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes.
  • Literature 1
    • Reference

    • Biomaterials. 2013 Apr;34(13):3511-22.
    • Author

    • Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.
    • Title

    • Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.