• DRAMP ID

    • DRAMP20777
    • Peptide Name

    • Cath-BF
    • Source

    • Bungarus fasciatus (Banded krait)
    • Family

    • Derived from three-finger toxin
    • Gene

    • Unknown
    • Sequence

    • KRFKKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF
    • Sequence Length

    • 34
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.29392557] Gram-positive bacteria: MRSA PS-2 (MIC=64 μg/ml);
      • Gram-negative bacteria, MRSA PS-7 (MIC=64 μg/ml), MRSA PS-18 (MIC=64 μg/ml), MRSA PS-45 (MIC=64 μg/ml), MRSA PS-46 (MIC=128 μg/ml), MRSA PS-50 (MIC=64 μg/ml), MRSA PS-59 (MIC=128 μg/ml), MRSA PS-70 (MIC=32 μg/ml), MRSA PS-84 (MIC=128 μg/ml), MRSA PS-106 (MIC=128 μg/ml), MRSA PS-131 (MIC=64 μg/ml), MRSA PS-139 (MIC=64 μg/ml), MRSA PS-162 (MIC=64 μg/ml), MRSA PS-165 (MIC=32 μg/ml), Staphylococcus aureus ATCC 25923 (MIC=16 μg/ml), Staphylococcus aureus ATCC 33591 (MIC=256 μg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 μg/ml), Escherichia coli ATCC 51446 (MIC=16 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=32 μg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=4 μg/ml)
    • Hemolytic activity

      • [Ref.29392557] 5% haemolysis at 1.0 μg/ml, 5% haemolysis at 2.0 μg/ml, 5% haemolysis at 4.0 μg/ml, 5% haemolysis at 8.0 μg/ml, 7% haemolysis at 16.0 μg/ml, 9% haemolysis at 31.2 μg/ml, 13% haemolysis at 62.5 μg/ml, 17% haemolysis at 125.0 μg/ml, 19% haemolysis at 250.0 μg/ml, 23% haemolysis at 500.0 μg/ml, 24% haemolysis at 1000.0 μg/ml against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP20777 helical wheel diagram
    • Formula

    • C203H335N57O39
    • Absent Amino Acids

    • CDHMNQTWY
    • Common Amino Acids

    • K
    • Mass

    • 4198.25
    • PI

    • 12.04
    • Basic Residues

    • 15
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 13
    • Boman Index

    • -8683
    • Hydrophobicity

    • -75.29
    • Aliphatic Index

    • 62.94
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP20777

DRAMP20777 chydropathy plot
    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.
  • Literature 1
    • Reference

    • J Microbiol. 2018 Feb;56(2):128-137.
    • Author

    • Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM.
    • Title

    • The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus.