• DRAMP ID

    • DRAMP20779
    • Peptide Name

    • Halictine 1 (bees,insects,animals)
    • Source

    • Halictus sexcinctus
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GMWSKILGHLIR
    • Sequence Length

    • 12
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antimicrobial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=3.8 μM), Pseudomonas aeruginosa(MIC=45.0 μM);
      • Gram-positive bacteria: Bacillus subtilis(MIC=0.8 μM), Staphylococcus aureus(MIC=7.7 μM)
    • Hemolytic activity

      • [Ref.20198492] LC50=82μM against rat red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP20779 helical wheel diagram
    • Formula

    • C65H107N19O14S
    • Absent Amino Acids

    • ACDEFNPQTVY
    • Common Amino Acids

    • GIL
    • Mass

    • 1410.74
    • PI

    • 11
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Boman Index

    • -229
    • Hydrophobicity

    • 36.67
    • Aliphatic Index

    • 130
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 500
    • Polar Residues

    • 3

DRAMP20779

    • Function

    • Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity.
  • Literature 1
    • Reference

    • Amino Acids. 2010 Aug;39(3):763-75.
    • Author

    • Monincová L, Budesínskμ M, Slaninová J, Hovorka O, Cvacka J, Voburka Z, Fucík V, Borovicková L, Bednárová L, Straka J, Cerovskμ V.
    • Title

    • Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.