General Information
-
DRAMP ID
- DRAMP20779
-
Peptide Name
- Halictine 1 (bees,insects,animals)
-
Source
- Halictus sexcinctus
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GMWSKILGHLIR
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=3.8 μM), Pseudomonas aeruginosa(MIC=45.0 μM);
- Gram-positive bacteria: Bacillus subtilis(MIC=0.8 μM), Staphylococcus aureus(MIC=7.7 μM)
-
Hemolytic Activity
-
- [Ref.20198492] LC50=82μM against rat red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20779.
Physicochemical Information
-
Formula
- C65H107N19O14S
Absent Amino Acids
- ACDEFNPQTVY
Common Amino Acids
- GIL
Mass
- 1410.74
PI
- 11
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +3
-
Boman Index
- -229
Hydrophobicity
- 0.367
Aliphatic Index
- 130
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 500
Polar Residues
- 3
DRAMP20779
Comments Information
Function
- Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity.
Literature Information
- ·Literature 1
-
Title
- Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.
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Pubmed ID
- 20198492
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Reference
- Amino Acids. 2010 Aug;39(3):763-75.
-
Author
- Monincová L, Budesínskμ M, Slaninová J, Hovorka O, Cvacka J, Voburka Z, Fucík V, Borovicková L, Bednárová L, Straka J, Cerovskμ V.