• DRAMP ID

    • DRAMP20780
    • Peptide Name

    • Halictine 2 (bees,insects,animals)
    • Source

    • Halictus sexcinctus
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GKWMSLLKHILK
    • Sequence Length

    • 12
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antimicrobial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=2.5μM), Pseudomonas aeruginosa(MIC=42.1);
      • Gram-positive bacteria: Bacillus subtilis(MIC=1.0μM), Staphylococcus aureus(MIC=8.1μM)
    • Hemolytic activity

      • [Ref.20198492] LC50=78.1μM against rat red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP20780 helical wheel diagram
    • Formula

    • C69H116N18O14S
    • Absent Amino Acids

    • ACDEFNPQRTVY
    • Common Amino Acids

    • KL
    • Mass

    • 1453.85
    • PI

    • 10.3
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Boman Index

    • 59
    • Hydrophobicity

    • 6.67
    • Aliphatic Index

    • 130
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 500
    • Polar Residues

    • 2

DRAMP20780

    • Function

    • Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity.
  • Literature 1
    • Reference

    • Amino Acids. 2010 Aug;39(3):763-75.
    • Author

    • Monincová L, Budesínskμ M, Slaninová J, Hovorka O, Cvacka J, Voburka Z, Fucík V, Borovicková L, Bednárová L, Straka J, Cerovskμ V.
    • Title

    • Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.