• • DRAMP ID

  • DRAMP20780

• • Peptide Name

  • Halictine 2 (bees,insects,animals)

• • Source

  • Halictus sexcinctus

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GKWMSLLKHILK

• • Sequence Length

  • 12

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=2.5μM), Pseudomonas aeruginosa(MIC=42.1);
    • Gram-positive bacteria: Bacillus subtilis(MIC=1.0μM), Staphylococcus aureus(MIC=8.1μM)

• • Hemolytic Activity

  • • [Ref.20198492] LC50=78.1μM against rat red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20780.

DRAMP20780

• • Function

  • Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity.

• ·Literature 1

• • Title

  • Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.

• • Pubmed ID

  • 20198492

• • Reference

  • Amino Acids. 2010 Aug;39(3):763-75.

• • Author

  • Monincová L, Budesínskμ M, Slaninová J, Hovorka O, Cvacka J, Voburka Z, Fucík V, Borovicková L, Bednárová L, Straka J, Cerovskμ V.