General Information

    • DRAMP ID

    • DRAMP20781

    • Peptide Name

    • Panurgine 1(bees,insects,animals)

    • Source

    • Panurgus calcaratus(communal bee)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LNWGAILKHIIK

    • Sequence Length

    • 12

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.23483218] Gram-negative bacteria: Escherichia coli(MIC=3.7μM), Pseudomonas aeruginosa(MIC=51.7μM) ;
      • Gram-positive bacteria: Micrococcus luteus(MIC=1.5μM), Bacillus subtilis(MIC=1.3μM), Staphylococcus aureus(MIC=10.6μM) ;
      • Yeast: Candida albicans(MIC=7.3μM)

    • Hemolytic Activity

      • [Ref.23483218] LC50=119μM against rat red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20781 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20781.

Physicochemical Information

    • Formula

    • C68H112N18O14

    • Absent Amino Acids

    • CDEFMPQRSTVY

    • Common Amino Acids

    • I

    • Mass

    • 1405.75

    • PI

    • 10

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • 728

    • Hydrophobicity

    • 0.592

    • Aliphatic Index

    • 170.83

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 2

DRAMP20781

Comments Information

    • Function

    • Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria, antifungal activity, and low hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae).

    • Reference

    • Amino Acids. 2013 Jul;45(1):143-57.

    • Author

    • Čujová S, Slaninová J, Monincová L, Fuμík V, Bednárová L, μtokrová J, Hovorka O, Voburka Z, Straka J, μeμovskμ V.