• DRAMP ID

    • DRAMP20781
    • Peptide Name

    • Panurgine 1(bees,insects,animals)
    • Source

    • Panurgus calcaratus(communal bee)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • LNWGAILKHIIK
    • Sequence Length

    • 12
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antimicrobial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.23483218] Gram-negative bacteria: Escherichia coli(MIC=3.7μM), Pseudomonas aeruginosa(MIC=51.7μM) ;
      • Gram-positive bacteria: Micrococcus luteus(MIC=1.5μM), Bacillus subtilis(MIC=1.3μM), Staphylococcus aureus(MIC=10.6μM) ;
      • Yeast: Candida albicans(MIC=7.3μM)
    • Hemolytic activity

      • [Ref.23483218] LC50=119μM against rat red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP20781 helical wheel diagram
    • Formula

    • C68H112N18O14
    • Absent Amino Acids

    • CDEFMPQRSTVY
    • Common Amino Acids

    • I
    • Mass

    • 1405.75
    • PI

    • 10
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • 728
    • Hydrophobicity

    • 59.17
    • Aliphatic Index

    • 170.83
    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 500
    • Polar Residues

    • 2

DRAMP20781

    • Function

    • Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria, antifungal activity, and low hemolytic activity against human erythrocytes.
  • Literature 1
    • Reference

    • Amino Acids. 2013 Jul;45(1):143-57.
    • Author

    • Čujová S, Slaninová J, Monincová L, Fuμík V, Bednárová L, μtokrová J, Hovorka O, Voburka Z, Straka J, μeμovskμ V.
    • Title

    • Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae).