General Information

    • DRAMP ID

    • DRAMP20782

    • Peptide Name

    • Pleurain-D1 (Frogs,amphibians,animals)

    • Source

    • Nidirana pleuraden (Yunnan pond frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.

    • Gene

    • Not found

    • Sequence

    • FLSGILKLAFKIPSVLCAVLKNC

    • Sequence Length

    • 23

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19028675] Gram-negative bacteria: Escherichia coli (MIC=25 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 μg/ml), Bacillus subtilis (MIC=50 μg/ml);
      • Yeast: Candida albicans(MIC=25 μg/ml)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20782 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20782.

Physicochemical Information

    • Formula

    • C117H197N27O27S2

    • Absent Amino Acids

    • DEHMQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2478.14

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • 2551

    • Hydrophobicity

    • 1.383

    • Aliphatic Index

    • 152.61

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.68

    • Polar Residues

    • 6

DRAMP20782

DRAMP20782 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

Literature Information

  • ·Literature 1

    • Title

    • Antioxidant peptidomics reveals novel skin antioxidant system.

    • Reference

    • Mol Cell Proteomics. 2009 Mar;8(3):571-83.

    • Author

    • Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R.