General Information

    • DRAMP ID

    • DRAMP20799

    • Peptide Name

    • XT-2 (frog, amphibians, animals)

    • Source

    • Xenopus tropicalis (Diploid clawed frog, Africa)

    • Family

    • Belongs to the Pipidae family.

    • Gene

    • Not found

    • Sequence

    • GCWSTVLGGLKKFAKGGLEAIVNPK

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.11738090] Gram-negative bacteria: Escherichia coli (MIC=8μM).

    • Hemolytic Activity

      • [Ref.11738090] HC50 is not determined against human red blood cells.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20799 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20799.

Physicochemical Information

    • Formula

    • C118H193N31O31S

    • Absent Amino Acids

    • DHMQRY

    • Common Amino Acids

    • G

    • Mass

    • 2574.08

    • PI

    • 9.63

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 105

    • Hydrophobicity

    • 0.184

    • Aliphatic Index

    • 93.6

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 9

DRAMP20799

DRAMP20799 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria (Escherichia coli).

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).

    • Reference

    • Biochim Biophys Acta 2001 Nov 26;1550(1):81-9.

    • Author

    • Ali MF, Soto A, Knoop FC, Conlon JM.