General Information

    • DRAMP ID

    • DRAMP20828

    • Peptide Name

    • TB_KKG6A

    • Source

    • Synthetic construct

    • Family

    • Derived from TB

    • Gene

    • Not found

    • Sequence

    • KKLLPIVANLLKSLL

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28443279] Gram-positive bacteria: S.aureus ATCC 33591 (MIC=1.5μM), Staphylococcus epidermidis (MIC=1.5μM);
      • Gram-negative bacteria: Klebsiella pneumoniae ATCC BAA-1706 (MIC=3μM), Pseudomonas aeruginosa ATCC 27853 (MIC=3μM)

    • Hemolytic Activity

      • [Ref.28443279] 11% hemolysis at 48μM, 55% hemolysis at 96μM against human red cells

    • Cytotoxicity

      • [Ref.28443279] IC50 = 49 μM against PBMCs.
      • IC50 = 16 μM against A549 cells

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20828 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20828.

Physicochemical Information

    • Formula

    • C80H147N19O18

    • Absent Amino Acids

    • CDEFGHMQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1663.16

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 1360

    • Hydrophobicity

    • 1.047

    • Aliphatic Index

    • 208

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP20828

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative and Gram-positive bacteria,antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide

    • Reference

    • Front Chem. 2017 Apr 11;5:24

    • Author

    • Grassi L, Maisetta G, Maccari G, Esin S, Batoni G.