General Information
-
DRAMP ID
- DRAMP20829
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Peptide Name
- ABP-dHC-Cecropin A
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Source
- Synthetic construct
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Family
- Derived from dHC
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Gene
- Not found
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Sequence
- RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKALGK
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Sequence Length
- 37
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Anti-Cancer
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Target Organism
-
- [Ref.28347740] Cancer cell lines: Leukemia cell lines K562 (IC50=349.5μM), Leukemia cell lines U937 (IC50=303.2μM), Leukemia cell lines THP-1 (IC50=228.5μM)
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Hemolytic Activity
-
- [Ref.28347740] 0% hemolysis at 0μM, 1% hemolysis at 800μM against human red cells
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Cytotoxicity
-
- [Ref.28347740] IC50 = 349.5 μM and CI = [304.0, 399.0] μM against K562 cells.
- IC50 = 303.2 μM and CI =[291.2, 315.3] μM against U937 cells. IC50 = 228.5 μM and CI = [199.1, 258.0] μM against THP-1 cells. The CI is the Confidence Interval of 90%.
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Free
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Nonterminal Modifications and Unusual Amino Acids
- None
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Stereochemistry
- L
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Structure
- Alpha helix
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Structure Description
- ABP-dHC-Cecropin A and its analog adopt a well-defined
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP20829.
Physicochemical Information
-
Formula
- C185H316N56O46
Absent Amino Acids
- CHMSY
Common Amino Acids
- K
Mass
- 4060.89
PI
- 11.17
Basic Residues
- 9
Acidic Residues
- 2
Hydrophobic Residues
- 16
Net Charge
- +7
-
Boman Index
- -5007
Hydrophobicity
- -0.187
Aliphatic Index
- 108.11
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 152.78
Polar Residues
- 7
DRAMP20829
Comments Information
Function
- Anticancer activity against the human leukemia cells
Literature Information
- ·Literature 1
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Title
- Selective cytotoxicity of the antibacterial peptide ABP-dHC-Cecropin A and its analog towards leukemia cells
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Pubmed ID
- 28347740
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Reference
- Eur J Pharmacol. 2017 May 15;803:138-147.
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Author
- Sang M, Zhang J, Zhuge Q