• • DRAMP ID

  • DRAMP20831

• • Peptide Name

  • IsCT1L1

• • Source

  • Synthetic construct

• • Family

  • Belongs to the scorpion NDBP 5 family

• • Gene

  • Not found

• • Sequence

  • ILGKLWEGLKSLF

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.28657596] Gram-positive bacteria:Staphylococcus aureus (MIC=50μg/mL);
    • Gram-negative bacteria: S. typhimurium (MIC=100μg/mL), Escherichia coli (MIC=50μg/mL)

• • Hemolytic Activity

  • • [Ref.28657596] 1% hemolysis at 10 μg/ml, 78% hemolysis at 50 μg/ml, 90% hemolysis at 100 μg/ml against human red cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20831.

DRAMP20831

• • Function

  • Antibacterial activity against the Gram-negative and Gram-positive bacteria

• ·Literature 1

• • Title

  • Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides

• • Pubmed ID

  • 28657596

• • Reference

  • Antibiotics (Basel). 2017 Jun 28;6(3).

• • Author

  • de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM.