• • DRAMP ID

  • DRAMP20834

• • Peptide Name

  • PLS

• • Source

  • Not found

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RWQWRWQWR

• • Sequence Length

  • 9

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.29551999] Gram-negative bacteria:E. faecalis-sensitive strain (MIC=25.6 μM),Staphylococcus aureus-sensitive strain (MIC=34.9 μM),,Staphylococcus aureus-resistant strain (MIC=25.0 μM);
    • Gram-positive bacteria:Klebsiella pneumoniaae-sensitive strain (MIC=30.7 μM),Klebsiella pneumoniaae-resistant strain (MIC=26.2 μM),Pseudomonas aeruginosa-sensitive strain (MIC=99.7 μM),Pseudomonas aeruginosa-resistant strain (MIC=107.2 μM)

• • Hemolytic Activity

  • • [Ref.29551999] 24.8% hemolysis at 100μM,50% hemolysis at >100μM against human red cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20834.

DRAMP20834

• • Function

  • Antibacterial activity against the Gram-negative and Gram-positive bacteria

• ·Literature 1

• • Title

  • Design, Synthesis and Evaluation of Branched RRWQWR-Based Peptides as Antibacterial Agents against Clinically Relevant Gram-Positive and Gram-Negative Pathogens

• • Pubmed ID

  • 29551999

• • Reference

  • Front Microbiol. 2018 Mar 2;9:329.

• • Author

  • Vega SC, Mart