General Information
-
DRAMP ID
- DRAMP20835
-
Peptide Name
- StII1-30 StII peptide derivative
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ALAGTIIAGASLTFQVLDKVLEELGKVSRK
-
Sequence Length
- 30
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Candidacidal
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- [Ref.29359791] HC50=42.5μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- The peptide at low concentration exists in a random coil conformation.Increasing the peptide concentration up to 300
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20835.
Physicochemical Information
-
Formula
- C141H243N37O42
Absent Amino Acids
- CHMNPWY
Common Amino Acids
- L
Mass
- 3128.7
PI
- 8.54
Basic Residues
- 4
Acidic Residues
- 3
Hydrophobic Residues
- 15
Net Charge
- +1
-
Boman Index
- -1179
Hydrophobicity
- 0.54
Aliphatic Index
- 133.33
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP20835
Comments Information
Function
- Antibacterial activity against the candida
Literature Information
- ·Literature 1
-
Title
- Insights on the structure-activity relationship of peptides derived from Sticholysin II.
-
Pubmed ID
- 29359791
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Reference
- Biopolymers. 2018 Jan 23.
-
Author
- Lima de Oliveira A, Maffud Cilli E, Ros U, Crusca E Jr, Lanio ME, Alvarez C, Schreier S, Aguiar Pertinhez T, Spisni A.