General Information

    • DRAMP ID

    • DRAMP20836

    • Peptide Name

    • StII16-35 StII peptide derivative

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VLDKVLEELGKVSRKIAVGI

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Candidacidal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.29359791] HC50=128μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Random coil conformation

    • Structure Description

    • The peptide displays a random coil conformation up to 1 mM and does not show any structure concentration

    • Helical Wheel Diagram

    • DRAMP20836 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20836.

Physicochemical Information

    • Formula

    • C98H176N26O28

    • Absent Amino Acids

    • CFHMNPQTWY

    • Common Amino Acids

    • V

    • Mass

    • 2166.63

    • PI

    • 8.47

    • Basic Residues

    • 4

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • -1286

    • Hydrophobicity

    • 0.535

    • Aliphatic Index

    • 160.5

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP20836

DRAMP20836 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the candida

Literature Information

  • ·Literature 1

    • Title

    • Insights on the structure-activity relationship of peptides derived from Sticholysin II.

    • Reference

    • Biopolymers. 2018 Jan 23.

    • Author

    • Lima de Oliveira A, Maffud Cilli E, Ros U, Crusca E Jr, Lanio ME, Alvarez C, Schreier S, Aguiar Pertinhez T, Spisni A.