General Information

    • DRAMP ID

    • DRAMP20837

    • Peptide Name

    • Pb-CATH1 Python bivittatus antimicrobial peptides peptide derivative

    • Source

    • Synthetic construct

    • Family

    • Derived from cathelicidin family

    • Gene

    • Not found

    • Sequence

    • KRVKRFKKFFRKIKKGFRKIFKKTKIFIGGT

    • Sequence Length

    • 31

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28630199]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=2μg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3μg/ml);S. typhimurium (ATCC 14028)(MIC=1.5μg/ml);
      • Gram-positive bacteria:Staphylococcus aureus (ATCC 29213)(MIC>128μg/ml);B. cereus (ATCC 10876)(MIC=46μg/ml)

    • Hemolytic Activity

      • [Ref.28630199] 0% hemolysis at 4μg/ml against human red blood cell; 1.4 ± 0.4% hemolysis at 8μg/ml against human red blood cell; 5.1 ± 0.5% hemolysis at 16μg/ml against human red blood cell;7.3 ± 0.6% hemolysis at 32μg/ml against human red blood cell; 12.2 ± 0.7% hemolysis at 64μg/ml against human red blood cell

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20837 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20837.

Physicochemical Information

    • Formula

    • C187H312N54O34

    • Absent Amino Acids

    • ACDEHLMNPQSWY

    • Common Amino Acids

    • K

    • Mass

    • 3860.88

    • PI

    • 12.5

    • Basic Residues

    • 15

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +15

    • Boman Index

    • -8145

    • Hydrophobicity

    • -0.79

    • Aliphatic Index

    • 59.68

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP20837

DRAMP20837 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive

Literature Information

  • ·Literature 1

    • Title

    • Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.

    • Reference

    • Antimicrob Agents Chemother. 2017 Aug 24;61(9).

    • Author

    • Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C.