General Information

    • DRAMP ID

    • DRAMP20839

    • Peptide Name

    • Xylopin

    • Source

    • Xylocopa appendiculata circumvolans

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFVALLKKLPLILKHLH

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28855917]Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=15.0μM);Micrococcus luteus (ATCC 10240)(MIC=1.9μM);Bacillus subtilis (ATCC 6633)(MIC=3.75μM);Streptococcus pyogenes (CS)(MIC=3.75μM);Streptococcus agalactiae (CS)(MIC=3.75μM);Enterococcus. faecalis (CS)(MIC=15.0μM);
      • Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=3.75μM);Pseudomonas aeruginosa (ATCC 27853)(MIC=7.5μM);Stenotrophomonas maltophilia (ATCC 13637)(MIC=3.75μM);Shigella boydii (CS)(MIC=3.75μM);Klebsiella pneumoniae (CS)(MIC=7.5μM);Serratia marcescens (CS)(MIC=7.5μM);Enterobacter cloacae (CS)(MIC=7.5μM);Proteus mirabilis (CS)(MIC>30μM);Morganella morgannii (CS)(MIC=30μM);Acinetobacter baumanii/calcoaceticus (CS)(MIC=3.75μM) ;
      • Yeasts:Candida albicans (ATCC 90112)(MIC=7.5μM);Sacharomyces cerevisae(MIC=3.75μM)

    • Hemolytic Activity

      • [Ref.28855917]IC50=25uM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Linear cationic alpha-helical

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20839 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20839.

Physicochemical Information

    • Formula

    • C96H162N24O18

    • Absent Amino Acids

    • CDEMNQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 1940.49

    • PI

    • 10.3

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • 1824

    • Hydrophobicity

    • 0.941

    • Aliphatic Index

    • 183.53

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP20839

Comments Information

    • Function

    • Antimicrobial and mast cell degranulating peptide which probably acts by forming pores in membranes (PubMed

Literature Information

  • ·Literature 1

    • Title

    • Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans.

    • Reference

    • J Venom Anim Toxins Incl Trop Dis. 2017 Aug 29;23:40.

    • Author

    • Kazuma K, Ando K, Nihei KI, Wang X, Rangel M, Franzolin MR, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K.