General Information
-
DRAMP ID
- DRAMP20865
-
Peptide Name
- the dimeric RRWQWR motif peptide molecule
-
Source
- Synthetic construct
-
Family
- Derived from bovine LfcinB6
-
Gene
- Not found
-
Sequence
- (RRWQWR)2-K-(Ahx)
-
Sequence Length
- 14
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=14 μg/ml; MBC=110 μg/ml), Staphylococcus aureus ATCC 33591 (MIC=55 μg/ml; MBC=110 μg/ml);
- Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=27 μg/ml; MBC=55 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=27 μg/ml; MBC=220 μg/ml)
-
Hemolytic Activity
-
- [Ref.29984236] 0% hemolysis at 5 μM, 1% hemolysis at 12 μM, 2% hemolysis at 22 μM, 2% hemolysis at 50 μM, 4% hemolysis at 100 μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Branched
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20865.
Physicochemical Information
-
Formula
Absent Amino Acids
Common Amino Acids
Mass
- 0
PI
- 0
Basic Residues
Acidic Residues
Hydrophobic Residues
Net Charge
-
Boman Index
- 0
Hydrophobicity
- 0
Aliphatic Index
- 0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
Absorbance 280nm
- 0
Polar Residues
DRAMP20865
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.
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Pubmed ID
- 29984236
-
Reference
- Biomed Res Int. 2018 Jun 10;2018:5252891
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Author
- Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Martínez Baquero, Jaiver E. Rosas Pérez.