General Information

    • DRAMP ID

    • DRAMP20866

    • Peptide Name

    • the tetrameric RRWQWR motif peptide molecule

    • Source

    • Synthetic construct

    • Family

    • Derived from bovine LfcinB6

    • Gene

    • Not found

    • Sequence

    • (RRWQWR)4-K2-(Ahx)2-C2

    • Sequence Length

    • 30

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=29 μg/ml; MBC=57 μg/ml), Staphylococcus aureus ATCC 33591 (MIC=57 μg/ml; MBC=57 μg/ml);
      • Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=29 μg/ml; MBC=115 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=57 μg/ml; MBC=115 μg/ml)

    • Hemolytic Activity

      • [Ref.29984236] 5% haemolysis at 5 μM, 10% haemolysis at 12 μM, 10% haemolysis at 22 μM, 0% haemolysis at 50 μM, 2% haemolysis at 100 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Branched

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond which links two dimeric motif peptides

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20866 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20866.

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

DRAMP20866

DRAMP20866 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.

    • Reference

    • Biomed Res Int. 2018 Jun 10;2018:5252891

    • Author

    • Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Martínez Baquero, Jaiver E. Rosas Pérez.