• • DRAMP ID

  • DRAMP20867

• • Peptide Name

  • the palindromic RRWQWR motif peptide molecule

• • Source

  • Synthetic construct

• • Family

  • Derived from bovine LfcinB6

• • Gene

  • Not found

• • Sequence

  • RWQWRWQWR

• • Sequence Length

  • 9

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=74 μg/ml; MBC=148 μg/ml), Staphylococcus aureus ATCC 33591 (MIC=9 μg/ml; MBC=74 μg/ml);
    • Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=74 μg/ml; MBC=148 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=74 μg/ml; MBC=148 μg/ml)

• • Hemolytic Activity

  • • [Ref.29984236] 0% haemolysis at 5 μM, 1% haemolysis at 12 μM, 0% haemolysis at 22 μM, 5% haemolysis at 50 μM, 25% haemolysis at 100 μM against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20867.

DRAMP20867

• • Function

  • Antibacterial activity against the Gram-positive and Gram-negative bacteria.

• ·Literature 1

• • Title

  • Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.

• • Pubmed ID

  • 29984236

• • Reference

  • Biomed Res Int. 2018 Jun 10;2018:5252891

• • Author

  • Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Martínez Baquero, Jaiver E. Rosas Pérez.