General Information
-
DRAMP ID
- DRAMP20869
-
Peptide Name
- Pal-ano-9 (Pal-anoplin peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide Pal-anoplin
-
Gene
- Not found
-
Sequence
- GLLKRIKTL
-
Sequence Length
- 9
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.406 μg/mL);
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.406 μg/mL);
- Fungi: Candida albicans ATCC 10231 (MIC=3.25 μg/mL).
-
Hemolytic Activity
-
- [Ref.29614317] HC50=18.92μg/mL against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Acylation (Gly1 conjugated with a palmitoyl group)
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20869.
Physicochemical Information
-
Formula
- C48H92N14O11
Absent Amino Acids
- ACDEFHMNPQSVWY
Common Amino Acids
- L
Mass
- 1041.35
PI
- 11.17
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +3
-
Boman Index
- -797
Hydrophobicity
- 0.278
Aliphatic Index
- 173.33
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP20869
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.
Literature Information
- ·Literature 1
-
Title
- Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
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Pubmed ID
- 29614317
-
Reference
- Peptides. 2018 Jun;104:7-14.
-
Author
- Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG.