General Information

    • DRAMP ID

    • DRAMP20872

    • Peptide Name

    • Pal-ano-6 (Pal-anoplin peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Pal-anoplin

    • Gene

    • Not found

    • Sequence

    • GLLKRI

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.61 μg/mL);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.25 μg/mL);
      • Fungi: Candida albicans ATCC 10231 (MIC=1.63 μg/mL).

    • Hemolytic Activity

      • [Ref.29614317] HC50=7.51μg/mL against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation (Gly1 conjugated with a palmitoyl group)

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20872 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20872.

Physicochemical Information

    • Formula

    • C32H62N10O7

    • Absent Amino Acids

    • ACDEFHMNPQSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 698.91

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -477

    • Hydrophobicity

    • 0.55

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP20872

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.

Literature Information

  • ·Literature 1

    • Title

    • Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.

    • Reference

    • Peptides. 2018 Jun;104:7-14.

    • Author

    • Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG.