General Information
-
DRAMP ID
- DRAMP20879
-
Peptide Name
- DAN1
-
Source
- Danaus plexippus (monarch butterfly)
-
Family
- Belongs to the cecropin family.
-
Gene
- KGM_210268
-
Sequence
- KWKIFKKIEKVGRNVRDGIIKAGPAVQVVGQATSIAK
-
Sequence Length
- 37
-
UniProt Entry
- A0A212EJN7
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=131.3μ±μ46.1 μg/mL);
- Gram-negative bacteria: Escherichia coli (MIC=4.9μ±μ2.3 μg/mL), Pseudomonas aeruginosa (MIC=7μ±μ0.8 μg/mL), Klebsiella pneumoniae (MIC=16.2μ±μ1.9 μg/mL)
-
Hemolytic Activity
-
- [Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Random coil
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20879.
Physicochemical Information
-
Formula
- C184H314N54O47
Absent Amino Acids
- CHLMY
Common Amino Acids
- K
Mass
- 4034.85
PI
- 10.73
Basic Residues
- 9
Acidic Residues
- 2
Hydrophobic Residues
- 16
Net Charge
- +7
-
Boman Index
- -4680
Hydrophobicity
- -0.16
Aliphatic Index
- 102.7
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 152.78
Polar Residues
- 7
DRAMP20879
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Identification and screening of potent antimicrobial peptides in arthropod genomes.
-
Pubmed ID
- 29501691
-
Reference
- Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.
-
Author
- Duwadi D, Shrestha A, Yilma B, Kozlovski I, Sa-Eed M, Dahal N, Jukosky J.